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当前位置:秒速赛车 > 产品展示 > Peprotech细胞因子 > 树突状细胞研究相关蛋白 > Peprotech公司 Recombinant Human Flt3-Ligand

Peprotech公司 Recombinant Human Flt3-Ligand
名称 Peprotech公司 Recombinant Human Flt3-Ligand
型号
报价 1
特点 Flt3-Ligand是一种生长因子,调节早期造血细胞的增殖。Flt3-Ligand结合细胞表达酪氨酸激酶受体Flt3。Flt3-Ligand,本身不刺激早期造血细胞的增殖,但synergizes与其他模型和白细胞介素诱导生长和分化。}
  • 详细内容

一.产品名称:

二。Catalog Number:

三.Synonyms:Fms-related tyrosine kinase 3 ligand

四.Description:

is a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation. Unlike , Flt3-Ligand exerts no activity on mast cells. Multiple isoforms of Flt3-Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.). The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform. Recombinant human Flt3-Ligand is a soluble 17.6 kDa protein consisting of 155 amino acid residues.

五.AA Sequence:

TQDCSFQHSP ISSDFAVKIR ELSDYLLQDY PVTVASNLQD EELCGGLWRL VLAQRWMERL KTVAGSKMQG LLERVNTEIH FVTKCAFQPP PSCLRFVQTN ISRLLQETSE QLVALKPWIT RQNFSRCLEL QCQPDSSTLP PPWSPRPLEA TAPTA

六.Source:E.coli

七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

八。Biological Activity:

The ED50 was determined by the dose-dependent stimulation of the proliferation of human AML5 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.

九。Cross Reactivity:Monkey, Mouse, Rat, Human, Leech, Human + Mouse, Rabbit

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